About DAXXIFY®
The active ingredient in DAXXIFY® is a purified protein called botulinum toxin type A.
DAXXIFY® could be for you if you would like to improve the look of your frown lines with a product that's fast acting, long lasting and improves the appearance of skin texture.* Or, if you’re interested in an innovative formula that does not use human or animal-based components found in traditional neurotoxins, DAXXIFY® could be for you.
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*In clinical trial diaries, patients reported seeing a measurable improvement within 2 days of treatment. 74% achieved a ≥ 2-grade improvement at week 4 per both physician's and patient’s assessment. More than 50% had no or minor frown lines until 6 months after treatment per both physician's and patient's assessments. In an open label study (N=27), 96% of patients agreed their skin looked smooth in the glabella (exploratory endpoint).
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In DAXXIFY®, they're part of the formulation that helps efficiently and effectively deliver the active botulinum toxin A, the protein responsible for helping smooth moderate to severe frown lines.
DAXXIFY® is unique because it is the only formulation that uses a novel peptide as a stabilizer, without any human or animal byproducts, helping the active ingredient form a strong bond with the neuron and remain available to enter the neuron over time.
The peptide formulation helps with the attachment of the active ingredient, acting like a magnet and helping the active toxin remain available to enter nerve cells. The unique formulation of DAXXIFY® helps deliver results that are fast, last, and give a radiant look to the skin’s texture after treatment.* The peptide also helps eliminate the need for human or animal products to stabilize the active ingredient, botulinum toxin A.
*In clinical trial diaries, patients reported seeing a measurable improvement within 2 days of treatment. 74% achieved a ≥ 2-grade improvement at week 4 per both physician's and patient’s assessment. More than 50% had no or minor frown lines until 6 months after treatment per both physician's and patient's assessments.
Units are usually unique to each manufacturer and formula, so not all Units are the same. If you have questions or concerns around your specific needs, talk to your current provider or find a DAXXIFY® provider near you.
The initial idea was to formulate botulinum toxin type A, the active ingredient in DAXXIFY®, with a peptide to see if it could be applied topically to the skin to treat crow’s feet wrinkles. Through this process, scientists discovered that the formulation was optimally administered through injection. Several clinical studies were created to determine the correct dose for an injectable product that would treat frown lines.
Safety
DAXXIFY® was studied in the largest-ever clinical study for a frown line treatment and included more than 2,800 people across different ages and skin types. Here are some things you should know about DAXXIFY®:
- There were no serious treatment-related side effects
- The active ingredient in DAXXIFY® is botulinum toxin type A, an ingredient that has been used in frown line treatments for more than 20 years
DAXXIFY® may cause serious side effects that can be life threatening. Please talk to your aesthetic provider about possible side effects and consult with the Prescribing Information and Medication Guide.
DAXXIFY® is well studied, with no serious treatment-related side effects seen in large-scale clinical trials. The most common side effects of DAXXIFY® include headache, eyelid drooping, and loss of ability to move the muscles in your face.
Preparing for your treatment
Ask your aesthetic provider for pre-treatment instructions prior to your DAXXIFY® appointment.
A list of common avoidances before treatment include, but are not limited to:
- Retin-A
- Blood thinners
- Muscle relaxants
- Fish or oils rich in omega 3
- Allergy medication
- Topical steroids
- Sleep medications and supplements
- Aspirin
- St. John’s Wort
- Supplements containing Vitamin E
If you are concerned about discomfort, talk to your injector about options for minimizing pain, such as icing the area or applying a topical numbing cream. Treatment with DAXXIFY® requires minimal downtime, and you can return to your daily routine immediately after your appointment.
There is a possibility that the area around the injection site will swell, turn red, and cause pain or tenderness from the injection itself; however, these side effects are typically very minor and go away after a few hours or days.
DAXXIFY® is long-lasting with gradual softening over time. This means your results won't just disappear one day. Instead, the muscle will slowly and subtly regain movement over a prolonged period.
In clinical trial diaries, more than 50% had no or minor frown lines until 6 months after treatment per both physician's and patient's assessments.
You may see results with DAXXIFY® as early as the next day after treatment, and typically within two days.*
*In clinical trial diaries, patients reported seeing a measurable improvement within 2 days of treatment.
You may see results with DAXXIFY® as early as the next day after treatment, and typically within two days. You should see noticeable results within a two-week time frame. You may experience mild injection-related bruising. In most cases, bruising heals within a few days after injection.*
*74% achieved a ≥ 2-grade improvement at week 4 per both physician's and patient’s assessment.
About wrinkles & injectable treatments
Facial lines are also formed by repeated muscle contractions such as frowning, squinting, or raising the eyebrows. These facial expressions cause the skin to furrow and fold, which eventually leads to the formation of wrinkles.
DAXXIFY® works below the skin's surface to temporarily reduce the underlying muscle activity responsible for moderate to severe frown lines.
DAXXIFY® is the only FDA-approved treatment (neurotoxin) formulated with a peptide that smooths moderate to severe lines between the brows.
Facial fillers, also known as dermal fillers, are typically made of hyaluronic acid and are used to add volume, fullness, and structure to areas of the face. They can help contour cheekbones, soften lines around the nose and mouth, and volumize lips. Dermal fillers target volume loss rather than muscle-related wrinkles.
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